Meredith Grey's best friend, better known as her "person" on the hit ABC show Grey's Anatomy, is leaving Seattle Grace after its 10th season.

Sandra Oh who has played complex Cristina Yang since the show's premiere in 2005, told "The Hollywood Reporter" that she is ready to go.

"Creatively, I really feel like I gave it my all, and I feel ready to let her go," Oh tells 'The Hollywood Reporter.'  "It's such an interesting thing to play a character for so long and to actually get the sense that she wants to be let go as well. [Cristina] wants to be let go, and I am ready to let her go. We have to start the process, story-wise, for the Grey's writers to think of why she's going to go."

Oh earned five supporting actress Emmy nominations for her role.  Show creator and friend Shonda Rhimes is sad to see her go.

 "This year is going to be bittersweet for us – we're both going to savor every moment of Cristina Yang and then we're going to give her the exit she deserves," Rhimes said in a statement.  "And when Sandra walks out of my door, Grey's Anatomy will once again be forever changed."

Season 10 of Grey's Anatomy premieres Sept. 26 on Local 10.