Four people were taken to the hospital Friday after a crash along the southbound Turnpike extension (SR 821) west of Red Road, troopers said.
A 2005 Jaguar and a 2013 Ford F-150 pulling a boat trailer were both southbound on the Turnpike.
The vehicles sideswiped each other, causing the 55-year-old driver of the F-150 to lose control, according to the Florida Highway Patrol.
The F-150 veered to the left and struck the guardrail and overturned over it, causing the trailer to jackknife and the boat to separate from the trailer.
Allmore Plummer and Tisha-Ann Plummer of Pembroke Pines, who were inside the Jaguar, were taken to Memorial West. Troopers said Terry Wesley Clifton and William J. Clifton of Jacksonville, who were inside the F-150, were taken to Memorial East.
The cause of the crash remains under investigation. Troopers said charges are pending.