Heavy rains, strong winds, and flooding are expected in Biloxi, Miss.  Memories of devastation seven years ago are motivating a lot of people to leave town.

David Wallis lived through Hurricane Katrina. He remembered how difficult it was to get little things, like a bottle of water.

“That was a big issue last time. Water and ice. There was no water and ice for days. You can do without the electricity and stuff for a few days, but gotta have that water," Wallis said.

On Monday Wallis and his wife picked up their prescriptions before leaving their home in Biloxi. The pharmacy stayed open even when a lot of businesses closed. Pharmacy employees say people have been coming mostly for their prescriptions.

Channel 4 watched people prepare for the worst. Many houses were already boarded up tight. Others quickly sawed wood and drilled down boards over windows.

Rod Strahan packed up his RV and headed east. He did the same thing for Katrina.

“I’m glad I’m getting out of harms way. It’s always bad to leave your house. Especially, after things happen, you wonder if your stuff is still safe or if it’s still in good shape. That’s what we hope to come back and find," said Strahan.

Schools and government offices are closed Tuesday and Wednesday. Police and emergency responders are out in full force waiting for Isaac’s landfall, which is expected late Tuesday, early Wednesday.