The incident happened before 3 p.m. Thursday along eastbound I-75 at Mile Marker 38.
Nancy Gilberti, of Tarpon Springs, was traveling eastbound in her 2004 Chevrolet Trailblazer on I-75 when authorities said she lost control and left the roadway on the south shoulder.
FHP said the Trailblazer overturned and Gilberti was pronounced dead at the scene.
The cause of the crash remains under investigation.
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