Teddy Bridgewater passed for two touchdowns and ran for another score in the return to his home city, and No. 20 Louisville remained unbeaten by holding off Florida International 28-21 on Saturday night.
Bridgewater played quarterback for Northwestern High School before playing under center for Louisivlle.
Senorise Perry rushed for 74 yards for the Cardinals (4-0), who trailed for the first time this season before controlling the second half and avenging last season's 24-17 loss to FIU.
Darian Mallary and Jake Medlock both rushed for touchdowns for the Panthers (1-3), whose losses have come against teams from the Atlantic Coast Conference, Conference USA and now the Big East. FIU starts Sun Belt play next week at Louisiana-Lafayette.
Mallary and Medlock both left the game with injuries, and top FIU running back Kedrick Rhodes also missed the game with a right leg injury.