Miami manager Ozzie Guillen was ejected after the top of the third inning of the Marlins' game against Arizona during an animated argument with first base umpire Angel Campos.
It was only the second time this season Guillen has been tossed.
Guillen's argument came after the Marlins' Donovan Solano was picked off trying to steal second.
Television replays showed batter Carlos Lee tried unsuccessfully tried to call time out just before Solano was picked off on a throw from pitcher Tyler Skaggs to first baseman Paul Goldschmidt, who threw to second baseman Aaron Hill.
The game was the opener of the first home doubleheader in the Diamondbacks' 15-year history.