Teddy Bridgewater threw four touchdown passes and Louisville's defense allowed a school-record 30 yards, helping the seventh-ranked Cardinals blow out Florida International 72-0 on Saturday.
It was the highest scoring game for the Cardinals (4-0) since a 73-10 victory over Murray State in 2007. It also matched the school's fourth-largest margin of victory.
Bridgewater hit DeVante Parker for two TD passes and Gerald Christian and Eli Rogers for one each before Will Gardner came in to throw another touchdown to Michaelee Harris in the fourth quarter. Dominique Brown, Senorise Perry, Michael Dyer and Brandon Radcliff rushed for scores.
Charles Gaines returned the second-half kickoff 93 yards for a TD and recovered a muffed punt to set up Bridgewater's second TD pass in the second quarter.
Louisville's defense meanwhile didn't allow FIU (0-4) a first down until early in the second quarter and just two overall.