Drew Shore scored twice for the first multi-goal game of his career and the Florida Panthers ended Pittsburgh's club-record 13-game home winning streak with a 5-1 win on Monday night.
Jonathan Huberdeau, Dmitry Kulikov and Shawn Matthias also scored for the Panthers, who beat Pittsburgh for the second time in three meetings this season.
Scott Clemmensen stopped 35 shots in his first start in three weeks as Florida ended a two-game losing streak.
Matt Niskanen scored the only goal for the Penguins as Pittsburgh lost at home for the first time since Nov. 13. Marc-Andre Fleury made 23 saves but lost for only the fourth time in his past 37 starts at Consol Energy Center.