LeBron James and Chris Bosh will sit out the Heat's final regular season game.
Head Coach Erik Spoelstra made the announcement at shootaround on Wednesday.
Greg Oden is expected to play for the Heat.
Dwyane Wade is expected to see limited action as he gets his legs back into shape before the start of the playoffs.
Wednesday night's game will have no impact on the Heat's playoff seeding.
Miami is locked in as the second seed in the East.
However, by the end of the night, Miami will know their opponent,
The Heat will either face the Charlotte Bobcats or Washington Wizards.
The Heat will host Game 1 of the first round on either Saturday or Sunday.