CAIRO (AP) — Iran struck two communities near Israel’s main nuclear research site late Saturday, leaving several people seriously injured, hours after its own Natanz main nuclear enrichment site was hit, as the war spun into a dangerous new direction at the start of its fourth week.

It marked the first time in the war that Israel’s nuclear research center has been targeted.

The Israeli military said its defenses were not able to intercept missiles that hit the southern cities of Dimona and Arad. Dozens of people were injured, emergency services said.

“The war is not close to ending,” said Israel’s army chief, Gen. Eyal Zamir.

Iran's health ministry said more than 1,500 people have been killed there so far, the state broadcaster reported.

Earlier, Iran targeted the joint U.K.-U.S. Diego Garcia military base in the Indian Ocean about 2,500 miles (4,000 kilometers) away, suggesting that Tehran has missiles that can go farther than previously acknowledged — or that it had used its space program for an improvised launch.

Residents said Iran’s capital saw heavy airstrikes as they marked the end of the holy month of Ramadan.

The U.S. and Israel have offered shifting rationales for the war, from hoping to foment an uprising that topples Iran’s leadership to eliminating its nuclear and missile programs and its support for armed proxies. There have been no signs of an uprising, while internet restrictions limit information from Iran.

The war’s effects are felt far beyond the Middle East, raising food and fuel prices.

It is not clear how much damage Iran has sustained in the U.S. and Israeli strikes that began Feb. 28 — or even who is truly in charge. Supreme Leader Ayatollah Mojtaba Khamenei has not been seen in public since being named to the role.

Israel denies responsibility for attack on Natanz

There was no leakage after the strike on the Natanz nuclear facility, nearly 220 kilometers (135 miles) southeast of Tehran, the Iranian judiciary’s official news agency, Mizan, said.

The U.N. nuclear watchdog has said the bulk of Iran’s estimated 970 pounds (440 kilograms) of enriched uranium is elsewhere, beneath the rubble at its Isfahan facility. The International Atomic Energy Agency said on X it was looking into the strike.

Israel’s military said it was “not aware” of a strike by it there. The Pentagon declined to comment. Russian Foreign Ministry spokesperson Maria Zakharova said such strikes posed a “real risk of catastrophic disaster throughout the Middle East.”

Iran later retaliated, targeting Israel’s nuclear program. Israel is believed to be the only Middle East nation with nuclear weapons, though its leaders refuse to confirm or deny their existence.

The IAEA said on X it had not received reports of damage to the Israeli center or abnormal radiation levels.

The Natanz facility was also hit in the first week of the war and in the 12-day war last June.

US can use Diego Garcia base to protect Strait of Hormuz

U.K. officials did not give details of the strike that targeted the Diego Garcia base Friday, which was unsuccessful. Britain’s Ministry of Defense described Iran as “lashing out across the region.”

It’s unclear how close the missiles came to the island. Iran previously asserted that it has limited its missile range to below 2,000 kilometers (over 1,200 miles).

But military experts said Iran may have used its space launch vehicle for an improvised firing. “If you’ve got a space program, you’ve got a ballistic missile program,” said Steve Prest, a retired Royal Navy commodore.

Israel’s army chief, however, said Iran had fired “a two-stage intercontinental ballistic missile.” There was no statement from Iran.

Britain has not participated in U.S.-Israeli attacks but has allowed U.S. bombers to use its bases to attack Iran’s missile sites. On Friday, the U.K. government said bombers could use Diego Garcia to attack sites used to target ships in the Strait of Hormuz.

Global pressure increases to get shipping back on track

As Iran threatens shipping on the Strait of Hormuz, the United Arab Emirates joined 21 other countries including the U.K., Germany, France and Japan in expressing "readiness to contribute to appropriate efforts to ensure safe passage.”

The Trump administration announced it was temporarily lifting sanctions on Iranian oil that was already loaded on ships as of Friday, but that does not increase oil production, a central factor in surging prices. The oil ministry of Iran, which has evaded sanctions for years, replied that it “essentially has no crude oil left in floating storage.”

The head of U.S. Central Command, Adm. Brad Cooper, asserted that Iran’s ability to attack vessels on the strait had been “degraded." He said 5,000-pound (2,270-kilogram) bombs were dropped earlier in the week on an underground facility along Iran’s coast used to store anti-ship cruise missiles and mobile missile launchers.

The U.S. is deploying three more amphibious assault ships and roughly 2,500 additional Marines to the Middle East, an official told The Associated Press. Two other U.S. officials confirmed that ships were deploying, without saying where they were headed. All three spoke on condition of anonymity to discuss the operations.

Gulf countries reported more attacks. A missile alert sounded Saturday night in Dubai. Saudi Arabia said it downed 20 drones in its east, home to major oil installations.

In Israel, 15 people have been killed by Iranian missiles and four others have died in the occupied West Bank. At least 13 U.S. military members have been killed, along with well over a dozen civilians in Gulf nations.

Israeli troops and Hezbollah militants clash in Lebanon

Israel's military said it was conducting a “targeted ground operation” in southern Lebanon and at least four militants were killed. Hezbollah said its fighters clashed with troops in the southern village of Khiam.

Israeli strikes targeting Hezbollah have killed more than 1,000 people and displaced more than 1 million, according to the Lebanese government. Hezbollah's civilian assets also have been targeted.

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Lawless reported from London and Lidman from Jerusalem. Sam Mednick in Tel Aviv, Israel, contributed to this report.

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